Spoilers within.
According to the TVGuide summary for R2 23, Schneizel is manipulating/controlling Nunnally, meaning that the 'enemy' business is either him twisting her thoughts or an outright forced!gunpoint!Nunnally declaration. If it's the former, then it'll be harder to deal with, but if it's the latter all they really need to do is take down Schneizel himself. And Schneizel, minus all of his fancy toys, seems kinda squishy.
Of course there is also the possibility that Nunnally really does all of a sudden, out of the blue hate Lelouch and Suzaku, but I'd rather not consider that because I have a major soft spot for her and, as bad as Lelouch can get, Schneizel is unquestionably worse. I mean, seriously. Even Charles thought that Schneizel was too ruthless.
And then there's C.C. We know that she really feels a strong bond with Lelouch, but what precisely does she have on her mind? Is she worried for him? Concerned about a plan of hers? We simply don't know. Does Schneizel even care that C.C. exists or is he just concerned with his death-from-above 1984 jerkassery?
What do you think?
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(Actually, though, we're being given hints that Nunnally is going to do things that she knows are evil so that she can join Lelouch in Hell. In either case, I do think she would do something entirely different if given a moment's chance. I definitely think she'll be the final wrench to wreck everybody else's plans.)
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As for Cornelia, if she weren't there, I'd be sure Schneizel was completely manipulating Nunnally.